While serous cystadenoma is the most common of them all, they rarely grow to large sizes unless. The histopathologic findings, diagnostic strategy, differential diagnosis, and treatment strategy of these generally benign but sometimes symptomatic lesions are discussed. Case report open access serous cystadenocarcinoma of. Serous cystadenoma sca of pancreas accounts for more than half of cystforming neoplasms and has been increasingly recognized with advancement of clinical imaging evaluations. Serous cystadenoma of the pancreas is a diagnosis being entertained with increasing frequency. Apr 06, 2017 cystic neoplasms of the pancreas are less common, accounting for about 1015% of all cystic pancreatic lesions. Macrocystic and solid variants have also been described.
Serous cystadenoma of the pancreas belsley 2008 cancer. Serous cystadenoma of pancreas is a benign tumor of pancreas. Serous cystadenoma sca of the pancreas, encompassing serous microcystic adenoma sma and serous oligocystic adenoma soa, accounts for 1% to 2% of exocrine pancreatic tumors. The most widely applicable radiographic test at the current time is helical ct scanning with thin cuts through the pancreas, which often can provide assistance in the differentiation between serous and mucinous neoplasms. Serous cystadenoma of the pancreas is commonly consid ered to be a benign. The origin and evolution of this disorder remain unclear, but even metastatic cases have an excellent prognosis. Typical macroscopic characteristics of serous cystadenoma of the pancreas consist of microcystic mass with a spongelike honeycomb aspect or central scar or both. Serous cystadenoma microcystic and oligocystic is relatively rare among pancreatic neoplasms 1, 2. Serous cystadenomas of pancreas are rare benign epithelial neoplasms, which predominantly occur in the pancreatic body and tail of elderly females. Majority of these tumors have microcystic appearance. These tumors are very similar to benign serous cystic neoplasms scns of the pancreas, except that they tend to be larger, are locally invasive, and present distant metastasis. Resection is generally carried out for symptoms, large size, or the inability to distinguish a serous cystic neoplasm from a mucinous lesion, which has greater.
Diseasefree survival was defined as the length of time. Innumerable small cysts producing a honeycomb appearance were. In contrast, serous cystadenoma is considered benign and are typically found incidentally. Serous cystadenocarcinoma of the pancreas is a rare but wellestablished entity. Once thought to be rare, cystic neoplasms of the pancreas are being diagnosed with increased frequency because of improvements in pancreatic imaging 14.
Discussion serous cystadenoma of pancreas is a rare benign cystic neoplasm constituting 12% of all exocrine pancreatic tumors. Abstract background the preoperative diagnosis of pancreatic serous cystadenoma sca is important because as a typically benign tumor. Its clinical and pathological recognition as a separate entity from the mucinous cystic neoplasms has been characterised by compagno and oertel 3, 4. Cystadenomas and cystadenocarcinomas of the pancreas. Ct of serous cystadenoma of the pancreas and mimicking. This article is brought to you for free and open access by the jefferson digital commons. Serous cystadenomas scas are benign tumors, and serous. Typical and atypical manifestations of serous cystadenoma. Serous cystadenoma of the pancreas is the most common benign pancreatic neoplasm. Nowadays, the current management of serous cystadenomas of the pancreas is essentially conservative. Mar 08, 2012 among this group of lesions, the serous cystadenoma is typically asymptomatic. Distal pancreatectomy was performed by laparotomy and histological and immunohistochemical. Dec 16, 2019 mucinous cystadenoma constitutes approximately 23% of all the resected pancreatic cystic lesions, and serous cystadenoma accounts for 16%.
The risk of malignant transformation seems to be low even in the longterm course 1. Serous cystadenoma of the pancreas libre pathology. Radiographic imaging is a potent tool with which to diagnose serous cystadenoma of the pancreas, but limitations exist. How is benign mucinous cystadenoma of pancreas treated. Classification of the adnexal masses histopathology results n % benign masses 45 100 serous cystadenoma 15 33. Management of pancreatic serous cystadenomas advances in. Three cases of pancreatic serous cystadenoma and endocrine. Cystic neoplasms of pancreas are relatively rare tumours that can be divided into serous and mucinous category. Rare presentation of serous cystadenoma as hemorrhagic cyst author. Tell a friend about us, add a link to this page, or visit the webmasters page for free fun content. Serous cystadenocarcinoma of the pancreas and serous.
Pancreatic serous cystadenoma with signs of compression em. Serous cystadenoma of pancreas is an uncommon form of cystic tumor of pancreas. This is a common benign ovarian tumor diagnosed by microscopic examination. Figure 1 large amount of free peritoneal air and free fluid alongside with evidence o metastatic liver disease. Serous cystadenoma definition of serous cystadenoma by. Ct of serous cystadenoma of the pancreas and mimicking masses. It is also known as serous microcystic adenoma, 1 and pancreatic serous cystadenoma. Complete blood count, liver function test, amylase level, ca 199, cea levels were within normal limits. Majority occurs in the body and tail, although 30% of the time they are seen in the head. Between january 1986 and october 1998 25 patients with serous cystic neoplasms of the pancreas were operated at our institution. Since 1978, 211 cases have been reported in the literature. Serous cystadenoma sca represents a form of pancreatic cystic neoplasm which accounts for 1015% of pancreatic tumors and is characterized by benign behavior and heterogeneous macroscopic features, although the microscopic structure of pancreatic sca is uniform, the macroscopic feature shows a wide heterogeneity. Commonly, pancreatic serous cystadenomas are considered to be benign neoplasms, whereas mucinous cystadenomas are thought.
Pancreatic serous cystadenoma with compression of the main. Rare presentation of serous cystadenoma as hemorrhagic cyst. Pancreatic serous cystadenoma is typically found in women accounting for 74% of cases with a mean age of 58 years 1699 years, and the tumor is usually located at the bodytail of the pancreas. All but one showed characteristic findings consisting of both cystic and solid components. Differential diagnosis of pancreatic serous cystadenoma.
Serous cystadenoma sca represents a form of pancreatic cystic neoplasm which accounts for 1015% of pancreatic tumors and is characterized by benign behavior and heterogeneous macroscopic features. Resected serous cystic neoplasms of the pancreas jefferson. The most common presentation is with numerous small cysts that give a honeycomb appearance microcystic variant, thin septa, and sometimes with a central scar. We report a case of serous cystadenoma of the pancreas mixed with mucinous cystadenoma.
Pancreas is an important gland which produces digestive juices as well as insulin and glucagon hormone needed for maintaining optimum level of sugar in the blood. Distal pancreatectomy was performed by laparotomy and histological and. Serous cystadenoma article about serous cystadenoma by the. It is rather clear from the literature that the differentiation between benign and malignant serous cystadenoma both histologically and clinically may be very difficult 911. May 11, 2018 how is benign mucinous cystadenoma of pancreas treated. Typical and atypical manifestations of serous cystadenoma of.
Three of the 25 tumours 12% showed a malignant behaviour on histological assessment, whereas two patients with serous cystadenoma 8% revealed an association with ductal adenocarcinoma. Doctors give trusted, helpful answers on causes, diagnosis, symptoms, treatment, and more. Serous cystadenoma of the pancreas, also referred as microcystic adenoma, is an uncommon type of benign cystic pancreatic neoplasm. The prevalence of cancer among serous cystadenomas is reported to be 3% since the first case reported in the literature in 1989. Serous cystadenoma of the pancreas is a benign cystic lesion of the pancreas. Cystic neoplasms of the pancreas are less common, accounting for about 1015% of all cystic pancreatic lesions. There is a recognized strong female predilection m. Although a lobulated contour is a specific feature of serous cystadenoma, it may be over looked on the initial ct evaluation fig. Cystadenomas represented 76% of all primary pancreatic cystic tumors 398522. Mcn, serous cystic neoplasm, rare cysts, neoadjuvant treatment, and. Serous cystadenoma of pancreas is mainly present in women, especially over the age of. Vhl associated cases are sometimes patchy, multifocal pancreas 2012. European evidencebased guidelines on pancreatic cystic.
Ten cases of cystadenoma or cystadenocarcinoma of the pancreas were examined by computed tomography ct. The pancreatic serous cystadenoma is an epithelial neoplasm that mostly affects women with a slight predominance in the pancreatic head. After haemodynamic stabilisation, an urgent abdominal ct scan revealed a large. Ovarian serous cystadenoma, also less precisely known as serous cystadenoma, is the most common ovarian neoplasm, representing 20% of ovarian neoplasms, and is benign it has a very superficial resemblance to the most common type of ovarian cancer serous carcinoma of the ovary under the microscope. Mucinous cystadenoma has considerable malignant potential, estimated to be between 10 and 50%. A 86year old patient known to have a serous cystadenoma of the pancreas treated conservatively.
Pancreatic serous cystadenoma is a benign tumour of pancreas. Benign ovarian cysts are one of the most common gynecological conditions occurring in the adolescent and reproductive age group. If there are no signs and symptoms, then a wait and watch approach has been recommended by some experts, since it is a benign condition. Jan, 2019 serous cystadenoma of pancreas is an uncommon benign tumor of the pancreas that forms as a cyst. In contrast to some of the other cystforming tumors of the pancreas such as the intraductal papillary mucinous neoplasm and the mucinous cystic neoplasm, serous cystic. Thus, surgical intervention should be proposed in a minority of patients with serous cystadenoma, and only for those who had uncertain diagnosis after systemic examinations or had symptoms 20, 21. Causes of ovarian serous cystadenoma answers on healthtap. Serous cystadenoma of the pancreas pubmed central pmc. The two most common cystic neoplasms of the pancreas are serous cystadenoma and mucinous cystic neoplasms.
Magnetic resonance imaging showed a hypervascular mass in the tail of the pancreas of a 72yearold female who presented with mild abdominal pain. Serous cystic neoplasms of the pancreas although they carry a realistic risk of malignancy, the predominant view is that they never become malignant. Additionally the presenting symptoms are not characteristic. Serous cystadenoma of the pancreas is commonly considered to be a benign. Differential diagnosis of pancreatic serous cystadenoma and. Large amount of free peritoneal air and free fluid alongside with. Serous cystadenoma article about serous cystadenoma by. Mucinous cystadenoma constitutes approximately 23% of all the resected pancreatic cystic lesions, and serous cystadenoma accounts for 16%. Although a lobulated contour is a specific feature of serous cystadenoma, it may be over. Serous cystadenomata scas are benign entities that historically have been described to constitute 1% of neoplasia from the exocrine pancreas. The first large series of pathologically proven serous cystadenoma was first described in 1978 21. Diagnostic criteria, potential for growth or malignancy, and outcomes are not well defined.
Pdf serous adenomas represent 12% of pancreatic neoplasms and typically are. Computed tomography of cystadenoma and cystadenocarcinoma. These are uncommon tumors and constitute about 12% of all pancreatic tumors. The natural history and malignant potential of serous cystadenomas differ significantly from that of other cystic neoplasms. In fact, once diagnosed correctly through ct scans, mri, eus, fna, serology and blood test studies, observation and routinely reassessment of asymptomatic lesions is indicated thereby avoiding a major operation and resulting morbidity and mortality 1 3. Jul 14, 2017 serous cystadenoma of pancreas is a benign tumor of pancreas. A patient with a history of a large pancreatic serous cystadenoma sca presented to the emergency department with abdominal pain and haemodynamic shock. Serous cystadenoma of pancreas is mainly present in women, especially over the age of 60 years. Aug 25, 2017 serous cystadenoma of pancreas is a benign tumor of pancreas. Serous microcystic cystadenocarcinoma of the pancreas with. Mixed serous cystadenoma with mucinous cystadenoma of the. In all, 106 patients diagnosed with serous cystadenoma were identified. Serous pancreatic cystadenomas are benign tumours and most cases are detected incidentally. Herein, we report a case of a solidtype serous cystadenoma of the pancreas which is the 16th case reported worldwide and the first ever reported in greece.
Serous cystadenoma of pancreas is an uncommon benign tumor of the pancreas that forms as a cyst. This cystic neoplasm is made up of several small cysts spread into a honeycomb like appearance. Cystic lesions of the pancreas are being identified in increasing numbers, both because of the frequent use of radiography and advances in imaging techniques. Serous cystadenoma of pancreas occur in adults in the age group of 2590 years, with average age of presentation being 60 years. Accounts for almost 50% of pancreatic cystic neoplasms.
Serous cystadenoma of the pancreas is a rare lesion thought to be almost invariably benign. Wed like to understand how you use our websites in order to improve them. The full text of this article is available in pdf format. Serous cystadenoma of pancreas radiology reference article. A 65yearold woman was admitted to our hospital for evaluation of a palpable, elastic, hard mass measuring 6 cm in diameter in the right upper quadrant of the abdomen. The treatment measures available for benign mucinous cystadenoma of pancreas include the following. Serous cystadenoma is more common than mucinous cystic neoplasm, with a ratio of about 2. Serous cystadenomas are the most common type of cystic neoplasm of the pancreas 5.
Serous cystadenoma of pancreas radiology reference. Mixed serous cystadenoma with mucinous cystadenoma of the pa. It typically occurs in women most tumors do not cause any signs and symptoms, but in some individuals, there may be abdominal pain, indigestion, and loss of appetite due to serous cystadenoma of pancreas. Cystadenomas and cystadenocarcinomas of the pancreas ncbi. An oligocystic serous cystadenoma appears as a multicystic or lobulated cystic lesion with septation in the head of the pancreas, whereas mucinous cystic neoplasms have smooth contours with or without septation, and intraductal papillary mucinous neoplasms have either a pleomorphic or a clubbed, fingerlike cystic shape.
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